Main Category: Alzheimer's / Dementia
Article Date: 21 Mar 2011 - 3:00 PDT window.fbAsyncInit = function() { FB.init({ appId: 'aa16a4bf93f23f07eb33109d5f1134d3', status: true, cookie: true, xfbml: true, channelUrl: 'http://www.medicalnewstoday.com/scripts/facebooklike.html'}); }; (function() { var e = document.createElement('script'); e.async = true; e.src = document.location.protocol + '//connect.facebook.net/en_US/all.js'; document.getElementById('fb-root').appendChild(e); }());
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Scientists have developed a new way of administering drugs to the brain to treat Alzheimer's disease, according to a study published last Sunday in 'Nature Biotechnology'.
Researchers at Oxford University injected exosomes - tiny particles naturally released by cells - into the blood of mice. They found that for the first time, using this 'natural' system they were able to transfer potential new drugs across the normally impermeable blood-brain barrier and into the brain.
This new technology was also found to reduce the production of the enzyme BACE1, which helps produce the plaques in the brain in Alzheimer's disease.
Alzheimer's Society comment:
'In this exciting study, researchers may have overcome a major barrier to the delivery of potential new drugs for many neurological diseases including Alzheimer's. The blood-brain barrier protects the brain from harmful chemicals, but also makes it difficult for drugs to reach the target cells. If this delivery method proves safe in humans, then we may see more effective drugs being made available for people with Alzheimer's in the future.'
'More research is now needed to see if this method would be effective for people with Alzheimer's. Dementia research is desperately underfunded. To make the breakthroughs we need, we must invest now.'
Dr Susanne Sorensen
Head of Research
Alzheimer's Society
Research reference: Alvarez-Erviti, Seow, Yin et al, 'Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes', Nature Biotechnology, 20 March 2011.
Source:
Alzheimer's Society
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